{"id":2043,"date":"2022-08-15T15:40:09","date_gmt":"2022-08-15T07:40:09","guid":{"rendered":"http:\/\/yjzx.yinternational.net\/?p=2043"},"modified":"2022-08-15T20:07:16","modified_gmt":"2022-08-15T12:07:16","slug":"%e4%b8%8d%e8%80%81%e8%8d%afnmn%e6%8a%97%e7%99%8c%e5%86%8d%e6%b7%bb%e6%9c%89%e5%88%a9%e8%af%81%e6%8d%ae%ef%bc%81%e5%b1%b1%e4%b8%9c%e5%a4%a7%e5%ad%a6%e6%9c%80%e6%96%b0%e7%a0%94","status":"publish","type":"post","link":"http:\/\/yjzx.yinternational.net\/?p=2043","title":{"rendered":"\u201c\u4e0d\u8001\u85e5\u201dNMN\u6297\u764c\u518d\u6dfb\u6709\u5229\u8b49\u64da\uff01\u5c71\u6771\u5927\u5b78\u6700\u65b0\u7814\u7a76\uff1aNMN\u53ef\u63d0\u5347NAD+\u6c34\u6e96\uff0c\u555f\u52d5\u81ea\u7136\u6bba\u50b7\u7d30\u80de\ufffc"},"content":{"rendered":"\n<p>\u8fd1\u671f\uff0c\u5c71\u6771\u5927\u5b78\u806f\u5408\u9f4a\u9b6f\u91ab\u9662\u5728\u9802\u7d1a\u671f\u520a\u300aHepatology\u300b\u4e0a\u767c\u6587\uff0c\u4ed6\u5011\u767c\u73fe\u88dc\u5145NMN\u53ef\u4ee5\u986f\u8457\u63d0\u5347\u81ea\u7136\u6bba\u50b7\uff08NK\uff09\u7d30\u80de\u7684\u6d3b\u6027\uff0c\u589e\u5f37\u5176\u6297\u816b\u7624\u53cd\u61c9\u3002NMN\u6297\u764c\u518d\u6dfb\u6709\u5229\u8b49\u64da\uff01<br><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"865\" height=\"226\" src=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72476.png\" alt=\"\" class=\"wp-image-2044\" srcset=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72476.png 865w, http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72476-300x78.png 300w, http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72476-768x201.png 768w\" sizes=\"(max-width: 865px) 100vw, 865px\" \/><\/figure><\/div>\n\n\n<p><\/p>\n\n\n\n<p class=\"has-text-align-center\" style=\"font-size:18px\"><strong>\u4e00\u3001NK\u7d30\u80de\u2014\u2014\u201c\u5168\u80fd\u578b\u201d\u514d\u75ab\u7d30\u80de<\/strong><\/p>\n\n\n\n<p><br>\u81ea\u7136\u6bba\u50b7\uff08NK\uff09\u7d30\u80de\u662f\u514d\u75ab\u7cfb\u7d71\u4e2d\u975e\u5e38\u91cd\u8981\u7684\u4e00\u7a2e\u7d30\u80de\uff0c\u4e3b\u8981\u8ca0\u8cac\u6bba\u50b7\u8001\u5316\u7d30\u80de\u3001\u764c\u7d30\u80de\u3001\u53d7\u75c5\u6bd2\u611f\u67d3\u7b49\u7570\u5e38\u7d30\u80de\u3002\u8207\u5e38\u898b\u7684T\u3001B\u6dcb\u5df4\u7d30\u80de\u4e0d\u540c\uff0c\u5b83\u7121\u9700\u63a5\u53d7\u514d\u75ab\u7cfb\u7d71\u7684\u7279\u6b8a\u6307\u4ee4\uff0c\u7121\u9700\u5176\u4ed6\u7d30\u80de\u7684\u914d\u5408\uff0c\u55ae\u7368\u5c31\u80fd\u8b58\u5225\u4e26\u6e05\u9664\u7570\u5e38\u7d30\u80de\u3002NK\u7d30\u80de\u517c\u5177\u514d\u75ab\u76e3\u8996\u3001\u514d\u75ab\u61c9\u7b54\u3001\u514d\u75ab\u8a18\u61b6\u9019\u4e09\u5927\u529f\u80fd\uff0c\u56e0\u6b64\u6709\u4eba\u7a31\u5b83\u70ba\u201c\u5168\u80fd\u578b\u201d\u514d\u75ab\u7d30\u80de\u3002<br>NK\u7d30\u80de\u7684\u80fd\u91cf\u4f86\u6e90\u4e3b\u8981\u662f\u8461\u8404\u7cd6\uff0c\u5982\u679c\u6211\u5011\u80fd\u589e\u5f37\u5176\u8461\u8404\u7cd6\u4ee3\u8b1d\uff0c\u90a3\u9ebcNK\u7d30\u80de\u7684\u6d3b\u6027\u6703\u96a8\u4e4b\u589e\u5f37\uff0c\u5c0d\u65bc\u764c\u7d30\u80de\u7684\u6bba\u50b7\u4e5f\u6703\u6709\u6240\u63d0\u5347\u3002\u773e\u6240\u5468\u77e5\uff0cNAD+\u5728\u80fd\u91cf\u4ee3\u8b1d\u4e2d\u662f\u7a2e\u95dc\u9375\u7269\u8cea\uff0c\u56e0\u6b64\uff0c\u5c71\u6771\u5927\u5b78\u7684\u7814\u7a76\u4eba\u54e1\u731c\u6e2c\u63d0\u9ad8NAD+\u6c34\u6e96\u6216\u80fd\u63d0\u9ad8NK\u7d30\u80de\u7684\u6d3b\u6027\uff0c\u5f9e\u800c\u589e\u5f37\u6297\u816b\u7624\u80fd\u529b\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-text-align-center\" style=\"font-size:18px\"><strong>\u4e8c\u3001NK\u7d30\u80de\u8207NAD+\u7684\u95dc\u4fc2<\/strong><\/p>\n\n\n\n<p><br><strong>No.1&nbsp;NK\u7d30\u80de\u555f\u52d5\u5f8cNAD+\u4ee3\u8b1d\u986f\u8457\u589e\u5f37<\/strong><br>\u70ba\u4e86\u78ba\u8a8dNAD+\u4ee3\u8b1d\u8207NK\u7d30\u80de\u4e4b\u9593\u7684\u95dc\u4fc2\uff0c\u7814\u7a76\u4eba\u54e1\u9996\u5148\u5c0d\u5c0f\u9f20\u6ce8\u5c04\u4e86\u7d30\u80de\u56e0\u6578IL-15\uff0c\u8a98\u767c\u5176\u708e\u75c7\uff0c\u5f9e\u800c\u555f\u52d5NK\u7d30\u80de\uff0c\u7d50\u679c\u986f\u793a\u67094\u500bNAD+\u4ee3\u8b1d\u76f8\u95dc\u57fa\u56e0\u548c2\u500bNAD+\u5408\u6210\u95dc\u9375\u9176\u8868\u9054\u660e\u986f\u4e0a\u8abf\uff0c\u8b49\u660e\u4e86NAD+\u4ee3\u8b1d\u5728NK\u7d30\u80de\u555f\u52d5\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u555f\u52d5\u5f8c\u7684NK\u7d30\u80de\u5176NAD+\u4ee3\u8b1d\u986f\u8457\u589e\u52a0\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"401\" height=\"286\" src=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72477.png\" alt=\"\" class=\"wp-image-2045\" srcset=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72477.png 401w, http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72477-300x214.png 300w\" sizes=\"(max-width: 401px) 100vw, 401px\" \/><figcaption>\u57161\uff1a\u7d93\u904eIL-15\u523a\u6fc0\uff0c\u6d3b\u5316\u7684NK\u7d30\u80de\u5176NAD+\u660e\u986f\u4ee3\u8b1d\u589e\u5f37<\/figcaption><\/figure><\/div>\n\n\n<p><\/p>\n\n\n\n<p><br><\/p>\n\n\n\n<p><strong>No.2&nbsp;NAD+\u63d0\u5347NK\u7d30\u80de\u7684\u6bba\u50b7\u529b<\/strong><br>\u7814\u7a76\u4eba\u54e1\u9806\u85e4\u6478\u74dc\uff0c\u9032\u4e00\u6b65\u5730\u63a2\u7d22\u4e86NAD+\u5728NK\u7d30\u80de\u4e2d\u6240\u767c\u63ee\u7684\u4f5c\u7528\uff0c\u9996\u5148\uff0cNAD+\u53ef\u4ee5\u4fc3\u9032IFN- \u03b3\u3001TNF- \u03b1\u3001\u7a7f\u5b54\u7d20\u7684\u7522\u751f\uff0c\u589e\u5f37NK\u7d30\u80de\u7684\u6bba\u50b7\u529b\uff0c\u5176\u6b21\uff0cNAD+\u9084\u80fd\u523a\u6fc0NK\u7d30\u80de\u7684\u589e\u6b96\u548c\u6e1b\u5c11NK\u7d30\u80de\u7684\u51cb\u4ea1\u3002\u7e3d\u7684\u4f86\u8aaa\uff0cNAD+\u65e2\u80fd\u589e\u5f37NK\u7d30\u80de\u7684\u514d\u75ab\u6bba\u50b7\u529f\u80fd\uff0c\u53c8\u80fd\u4fdd\u8b77NK\u7d30\u80de\u3002<\/p>\n\n\n\n<p><br><img loading=\"lazy\" decoding=\"async\" width=\"442\" height=\"439\" src=\"\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"442\" height=\"439\" src=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72478.png\" alt=\"\" class=\"wp-image-2046\" srcset=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72478.png 442w, http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72478-300x298.png 300w, http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72478-150x150.png 150w\" sizes=\"(max-width: 442px) 100vw, 442px\" \/><figcaption>\u57162\uff1aNAD+\u4fc3\u9032NK\u7d30\u80de\u7522\u751fIFN- \u03b3\u3001TNF- \u03b1\u3001CD107a\u3001\u7a7f\u5b54\u7d20\u7684\u7522\u751f<\/figcaption><\/figure><\/div>\n\n\n<p><br><\/p>\n\n\n\n<p><strong>No.3&nbsp;NK\u7d30\u80de\u4e2dNAD+\u7684\u5408\u6210\u9014\u5f91<\/strong><br>\u65e2\u7136NAD+\u5c0dNK\u7d30\u80de\u5982\u6b64\u91cd\u8981\uff0c\u88dc\u5145NAD+\u6216\u80fd\u63d0\u5347NK\u7d30\u80de\u7684\u6297\u764c\u6d3b\u6027\u3002\u56e0\u6b64\uff0c\u6211\u5011\u5fc5\u9808\u641e\u6e05\u695aNAD+\u5728NK\u7d30\u80de\u7684\u5408\u6210\u9014\u5f91\uff0c\u9019\u6a23\u624d\u80fd\u9078\u64c7\u5408\u9069\u7684\u88dc\u5145\u7269\u8cea\u4f86\u63d0\u5347NK\u7d30\u80de\u4e2d\u7684NAD+\u6c34\u6e96\u3002<br>\u773e\u6240\u5468\u77e5\uff0cNAD+\u7684\u5408\u6210\u9014\u5f91\u4e3b\u8981\u6709\u4e09\u7a2e\uff1a\u5f9e\u982d\u5408\u6210\u3001Preiss-Handler\u9014\u5f91\u548c\u88dc\u6551\u5408\u6210\u9014\u5f91\u3002\u70ba\u4e86\u78ba\u5b9a\u5728NK\u7d30\u80de\u4e2d\u7a76\u7adf\u662f\u54ea\u4e00\u7a2e\u5408\u6210\u9014\u5f91\uff0c\u7814\u7a76\u4eba\u54e1\u9996\u5148\u5c0dNK\u7d30\u80de\u9032\u884c16\u5c0f\u6642\u7684\u9951\u9913\u8655\u7406\uff0c\u767c\u73fe\u7d66\u4e88NMN\u80fd\u901a\u904e\u88dc\u6551\u9014\u5f91\u6709\u6548\u63d0\u5347NAD+\u542b\u91cf\u3002<br>\u70ba\u4e86\u9032\u4e00\u6b65\u9a57\u8b49\u9019\u4e00\u7d50\u8ad6\uff0c\u7814\u7a76\u4eba\u54e1\u9084\u52a0\u5165\u4e86NAMPT\u7684\u9078\u64c7\u6027\u6291\u5236\u5291FK866\u4f86\u9a57\u8b49\uff0cNAMPT\u662fNAD+\u88dc\u6551\u9014\u5f91\u4e2d\u7684\u9650\u901f\u9176\uff0c\u6291\u5236\u8a72\u9176\u6d3b\u6027\uff0c\u5c31\u80fd\u6291\u5236NAD+\u88dc\u6551\u5408\u6210\u7684\u901f\u7387\u3002\u6b63\u5982\u6211\u5011\u6240\u9810\u6599\u7684\uff0cNAD+\u7684\u6c34\u6e96\u51fa\u73fe\u4e86\u4e0b\u964d\uff0c\u9019\u8aaa\u660eNK\u7d30\u80de\u4e2dNAD+\u5408\u6210\u9014\u5f91\u7684\u78ba\u662f\u88dc\u6551\u5408\u6210\u9014\u5f91\u3002<\/p>\n\n\n\n<p><br><img loading=\"lazy\" decoding=\"async\" width=\"278\" height=\"400\" src=\"\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"278\" height=\"400\" src=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72479.png\" alt=\"\" class=\"wp-image-2047\" srcset=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72479.png 278w, http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u72479-209x300.png 209w\" sizes=\"(max-width: 278px) 100vw, 278px\" \/><figcaption>\u57163\uff1a\u52a0\u5165NAMPT\u6291\u5236\u5291\u5f8cNK\u7d30\u80de\u7684NAD+\u6c34\u6e96\u986f\u8457\u4e0b\u964d<\/figcaption><\/figure><\/div>\n\n\n<p><\/p>\n\n\n\n<p><strong>No.4&nbsp;\u610f\u5916\u4e4b\u559c\uff01NAD+\u9084\u80fd\u6539\u5584\u7dda\u7c92\u9ad4\u7a69\u614b<\/strong><br>\u6709\u8da3\u7684\u4e8b\u60c5\u767c\u751f\u4e86\uff0c\u7814\u7a76\u4eba\u54e1\u5728\u4f7f\u7528NAMPT\u6291\u5236\u5291FK866\u6642\uff0c\u610f\u5916\u767c\u73feNK\u7d30\u80de\u4e2d\u7dda\u7c92\u9ad4\u547c\u5438\u93c8\u76f8\u95dc\u57fa\u56e0\u7684\u8868\u9054\u986f\u8457\u4e0b\u964d\uff0c\u540c\u6642\uff0c\u7d30\u80de\u8cea\u4e2d\u5b58\u5728\u5c0f\u7684\u3001\u7834\u788e\u7684\u7684\u7dda\u7c92\u9ad4\uff0c\u9032\u4e00\u6b65\u5730\u5206\u6790\u767c\u73fe\u7dda\u7c92\u9ad4\u7684\u54c1\u8cea\u548c\u819c\u96fb\u4f4d\u90fd\u51fa\u73fe\u4e86\u4e0b\u964d\uff0c\u800c\u88dc\u5145NMN\u6703\u8b93\u9019\u7a2e\u60c5\u6cc1\u6709\u6240\u597d\u8f49\uff0c\u9019\u6b21\u610f\u5916\u767c\u73fe\u8aaa\u660eNAD+\u5728NK\u7d30\u80de\u4e2d\u9084\u6709\u5176\u4ed6\u4f5c\u7528\uff0c\u80fd\u6709\u6548\u6539\u5584\u7dda\u7c92\u9ad4\u7684\u7a69\u614b\u548c\u7d30\u80de\u7684\u80fd\u91cf\u4ee3\u8b1d\u3002<br>\u7e3d\u7684\u4f86\u8aaa\uff0c\u7814\u7a76\u4eba\u54e1\u767c\u73feNAD+\u5c0d\u65bcNK\u7d30\u80de\u975e\u5e38\u91cd\u8981\uff0c\u662f\u5b83\u767c\u63ee\u5176\u529f\u80fd\u548c\u751f\u5b58\u7684\u57fa\u77f3\uff0c\u5176\u5408\u6210\u9014\u5f91\u4e3b\u8981\u662f\u88dc\u6551\u5408\u6210\uff0c\u56e0\u6b64\uff0c\u88dc\u5145NMN\u5c0dNK\u7d30\u80de\u7684NAD+\u6c34\u6e96\u7684\u63d0\u5347\u662f\u6709\u6548\u7684\uff0c\u53ef\u4ee5\u589e\u5f37\u5176\u6d3b\u6027\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-text-align-center\" style=\"font-size:18px\"><strong>\u4e09\u3001\u764c\u7d30\u80de\u70ba\u4f55\u80fd\u9003\u812bNK\u7d30\u80de\u7684\u201c\u8ffd\u6bba\u201d?<\/strong><\/p>\n\n\n\n<p><br><strong>No.1\u00a0\u816b\u7624\u7d30\u80de\u5c0d\u6297NK\u201c\u8ffd\u6bba\u201d\u7684\u79d8\u5bc6\u6b66\u5668<\/strong><br>\u7406\u8ad6\u4e0a\u4f86\u8aaa\uff0c\u5982\u679c\u764c\u7d30\u80de\u958b\u59cb\u589e\u6b96\uff0cNK\u7d30\u80de\u61c9\u8a72\u6703\u88ab\u5927\u91cf\u555f\u52d5\uff0c\u6703\u201c\u8ffd\u6bba\u201d\u90a3\u4e9b\u525b\u958b\u59cb\u589e\u6b96\u7684\u764c\u7d30\u80de\uff0c\u53ef\u70ba\u4f55\u764c\u75c7\u9084\u662f\u5927\u6416\u5927\u64fa\u5730\u589e\u6b96\u5462\uff1f\u96e3\u9053NK\u7d30\u80de\u201c\u7761\u8457\u201d\u4e86\uff1f\u79d1\u5b78\u5bb6\u767c\u73fe\u9084\u771f\u662f\u9019\u6a23\uff0c\u9b54\u9ad8\u4e00\u5c3a\uff0c\u9053\u9ad8\u4e00\u4e08\uff0c\u764c\u7d30\u80de\u70ba\u4e86\u4e0d\u88ab\u6d88\u6ec5\uff0c\u4e5f\u6709\u5b83\u7684\u201c\u79d8\u5bc6\u6b66\u5668\u201d\u2014\u2014\u816b\u7624\u5fae\u74b0\u5883\u3002<br>\u816b\u7624\u7d30\u80de\u53ef\u4ee5\u901a\u904e\u81ea\u5206\u6ccc\u548c\u65c1\u5206\u6ccc\uff0c\u6539\u8b8a\u5468\u570d\u7684\u74b0\u5883\uff0c\u5275\u9020\u51fa\u6709\u5229\u65bc\u81ea\u5df1\u751f\u9577\u548c\u767c\u5c55\u7684\u74b0\u5883\uff0c\u6211\u5011\u7a31\u4e4b\u70ba\u816b\u7624\u5fae\u74b0\u5883\u3002\u5148\u524d\u7684\u7814\u7a76\u767c\u73fe\uff0c\u816b\u7624\u5fae\u74b0\u5883\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u524a\u5f31\u4e86NK\u7d30\u80de\u7684\u6297\u816b\u7624\u529f\u80fd\uff0c\u5305\u62ec\u6bba\u6b7b\u816b\u7624\u548c\u7522\u751f\u7d30\u80de\u56e0\u6578\u3002\u800c\u9019\u6b63\u662fNAD+\u767c\u63ee\u4f5c\u7528\u7684\u9818\u57df\uff0c\u7814\u7a76\u4eba\u54e1\u63a8\u6e2c\u53ef\u80fd\u662f\u816b\u7624\u5fae\u74b0\u5883\u6291\u5236NAD+\u7684\u5408\u6210\u3002<br>\u70ba\u4e86\u8b49\u660e\u9019\u9ede\uff0c\u7814\u7a76\u4eba\u54e1\u63a1\u7528\u4e86\u5c0f\u9f20\u809d\u764c\u689d\u4ef6\u7684\u57f9\u990a\u57fa(HCM)\u4f86\u6a21\u64ec\u816b\u7624\u5fae\u74b0\u5883\uff0c\u767c\u73fe\u5728\u9019\u7a2e\u74b0\u5883\u4e0b\uff0cNK\u7d30\u80de\u4e2dNAD+\u6c34\u6e96\u548cNAMPT\u7684\u8868\u9054\u90fd\u986f\u8457\u4e0b\u964d\uff0c\u8b49\u5be6\u4e86\u7814\u7a76\u4eba\u54e1\u7684\u731c\u6e2c\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"865\" height=\"309\" src=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u724710.png\" alt=\"\" class=\"wp-image-2048\" srcset=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u724710.png 865w, http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u724710-300x107.png 300w, http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/\u56fe\u724710-768x274.png 768w\" sizes=\"(max-width: 865px) 100vw, 865px\" \/><figcaption>\u57164\uff1a\u5c0f\u9f20\u809d\u764c\u689d\u4ef6\u57f9\u990a\u57fa(HCM)\u986f\u8457\u964d\u4f4e\u4e86NAD+\u6c34\u6e96\u548cNAMPT\u7684\u8868\u9054<\/figcaption><\/figure><\/div>\n\n\n<p><strong>No.2&nbsp;\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u771f\u6b63\u7684\u201c\u7f6a\u9b41\u798d\u9996\u201d<\/strong><br>\u7576\u7136\u7814\u7a76\u4eba\u54e1\u4e0d\u6eff\u8db3\u65bc\u6b64\uff0c\u5fc5\u9808\u8981\u627e\u51fa\u816b\u7624\u5fae\u74b0\u5883\u6291\u5236NAD+\u5408\u6210\u7684\u201c\u7f6a\u9b41\u798d\u9996\u201d\uff0c\u6839\u64da\u4e00\u4e9b\u86db\u7d72\u99ac\u8de1\uff0c\u5f88\u5feb\u5c31\u78ba\u5b9a\u4e86\u201c\u7f6a\u9b41\u798d\u9996\u201d\u2014\u2014\u4e73\u9178\u3002\u70ba\u4e86\u9032\u4e00\u6b65\u78ba\u5b9a\u9019\u4e00\u7d50\u8ad6\uff0c\u7814\u7a76\u4eba\u54e1\u7528\u4e73\u9178\u8655\u7406\u4e86NK\u7d30\u80de\uff0cNAMPT\u679c\u7136\u51fa\u73fe\u4e0b\u8abf\uff0c\u800c\u666e\u901a\u7684\u9178\u5316\u4e26\u672a\u51fa\u73fe\u9019\u7a2e\u60c5\u6cc1(\u6392\u9664\u4e86PH\u7684\u5f71\u97ff),\u8868\u660e\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u8f03\u9ad8\u7684\u4e73\u9178\u74b0\u5883\u4f7f\u5f97NK\u7d30\u80de\u7684NAD+\u4ee3\u8b1d\u53d7\u5230\u6291\u5236\uff0c\u964d\u4f4e\u4e86NK\u7d30\u80de\u7684\u6d3b\u6027\uff0c\u5f9e\u800c\u524a\u5f31\u4e86\u6bba\u50b7\u816b\u7624\u7d30\u80de\u7684\u80fd\u529b\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center\" style=\"font-size:18px\"><br><strong>\u56db\u3001\u88dc\u5145NMN\u80fd\u5426\u6297\u764c\uff1f<\/strong><\/p>\n\n\n\n<p><br>\u524d\u9762\u5df2\u7d93\u8b49\u660e\u4e86\u63d0\u5347NAD+\u6c34\u6e96\u80fd\u589e\u5f37NK\u7d30\u80de\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u6548\u63d0\u5347\u6297\u816b\u7624\u6d3b\u6027\u3002\u800cNK\u7d30\u80de\u4e2dNAD+\u5408\u6210\u70ba\u88dc\u6551\u5408\u6210\u9014\u5f91\uff0c\u56e0\u6b64\u88dc\u5145NMN\u5f88\u53ef\u80fd\u662f\u53ef\u4ee5\u6297\u764c\u7684\u3002<br>\u7814\u7a76\u4eba\u54e1\u70ba\u4e86\u9a57\u8b49\u9019\u4e00\u731c\u6e2c\uff0c\u9032\u884c\u4e86\u591a\u9805\u5be6\u9a57\uff0c\u7d50\u679c\u986f\u793a\u88dc\u5145NMN\u7684\u5c0f\u9f20\u5176\u809d\u764c\u7d30\u80de\u5f97\u5230\u986f\u8457\u6291\u5236\uff0c\u5c0f\u9f20\u5b58\u6d3b\u7387\u660e\u986f\u5347\u9ad8\uff0c\u816b\u7624\u5fae\u74b0\u5883\u5c0dNK\u7d30\u80de\u6d3b\u6027\u7684\u6291\u5236\u660e\u986f\u6e1b\u5f31\uff0c\u9019\u4e9b\u767c\u73fe\u7a81\u51fa\u4e86NMN\u6cbb\u7642NK\u7d30\u80de\u6297\u816b\u7624\u514d\u75ab\u7684\u6cbb\u7642\u6f5b\u529b\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"250\" src=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/8390b2d1c15e572c9953c292fb063b7.jpg\" alt=\"\" class=\"wp-image-2049\" srcset=\"http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/8390b2d1c15e572c9953c292fb063b7.jpg 400w, http:\/\/yjzx.yinternational.net\/wp-content\/uploads\/2022\/08\/8390b2d1c15e572c9953c292fb063b7-300x188.jpg 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/figure><\/div>\n\n\n<p><\/p>\n\n\n\n<p class=\"has-text-align-center\" style=\"font-size:18px\"><strong>\u4e94\u3001\u7e3d\u7d50<\/strong><\/p>\n\n\n\n<p><br>\u9019\u9805\u7814\u7a76\u7684\u4e7e\u8ca8\u6bd4\u8f03\u591a\uff0c\u5c0d\u65bc\u5f88\u591a\u95dc\u9375\u6027\u7d50\u8ad6\u90fd\u662f\u901a\u904e\u591a\u6b21\u5be6\u9a57\u4f86\u9a57\u8b49\u7684\uff0c\u767c\u5728\u9802\u7d1a\u671f\u520a\u4e0d\u662f\u6c92\u6709\u9053\u7406\u7684\u3002\u6211\u5011\u4f86\u68b3\u7406\u4e00\u4e0b\uff0c<br>\u9996\u5148\uff0c\u7814\u7a76\u4eba\u54e1\u5f04\u6e05\u695a\u4e86NAD+\u8207NK\u7d30\u80de\u4e4b\u9593\u7684\u95dc\u4fc2\uff0c\u6253\u901a\u4e86NAD+\u2192NK\u7d30\u80de\u9019\u4e00\u74b0\u7bc0\uff0c\u5c24\u5176\u662f\u5f04\u6e05\u695a\u4e86NAD+\u7684\u5408\u6210\u9014\u5f91\u662f\u88dc\u6551\u5408\u6210\u9014\u5f91\u9019\u4e00\u9ede\uff0c\u9019\u610f\u5473\u8457\u88dc\u5145NMN\u80fd\u63d0\u5347NK\u7d30\u80de\u7684NAD+\u6c34\u6e96\u3002<br>\u5176\u6b21\uff0c\u5f04\u6e05\u695a\u4e86\u816b\u7624\u7d30\u80de\u6291\u5236NK\u7d30\u80de\u7684\u6bba\u50b7\u80fd\u529b\u7684\u539f\u56e0\u662f\u6291\u5236\u4e86NAD+\u7684\u5408\u6210\u4ee3\u8b1d\uff0c\u6253\u901a\u4e86NAD+\u2192NK\u7d30\u80de\u2192\u816b\u7624\u7d30\u80de\u9019\u6574\u500b\u904e\u7a0b,\u8b49\u660e\u4e86\u88dc\u5145NAD+\u662f\u53ef\u4ee5\u5177\u6709\u6297\u816b\u7624\u6d3b\u6027\u7684\u3002\u5169\u500b\u7d50\u8ad6\u76f8\u7d50\u5408\uff0c\u53ef\u4ee5\u5f97\u51fa\u88dc\u5145NMN\u5f88\u53ef\u80fd\u5177\u6709\u6297\u764c\u7684\u6f5b\u529b\uff0c\u4e26\u4e14\u7528\u5927\u91cf\u5be6\u9a57\u53bb\u9a57\u8b49\u4e86\u9019\u4e00\u731c\u6e2c\u3002<br>\u4f46\u9019\u9805\u7814\u7a76\u4e5f\u6709\u4e00\u5b9a\u7684\u5c40\u9650\u6027\uff0c\u9996\u5148\uff0c\u5b83\u7684\u764c\u75c7\u7814\u7a76\u5c0d\u8c61\u662f\u809d\u764c\u7d30\u80de\uff0c\u5c0d\u65bc\u5176\u4ed6\u985e\u578b\u7684\u764c\u7d30\u80de\u4e26\u672a\u7814\u7a76\uff0c\u5176\u6b21\uff0c\u5be6\u9a57\u57fa\u672c\u70ba\u52d5\u7269\u5be6\u9a57\u548c\u9ad4\u5916\u5be6\u9a57\uff0c\u88dc\u5145NMN\u5728\u4eba\u9ad4\u4e0a\u7684\u6297\u816b\u7624\u6d3b\u6027\u9700\u8981\u9032\u4e00\u6b65\u5730\u9a57\u8b49\u3002<br>\u9019\u9805\u7814\u7a76\u5c0dNMN\u7b97\u662f\u500b\u597d\u6d88\u606f\uff0c\u8aaa\u660eNMN\u5177\u6709\u6297\u764c\u7684\u6f5b\u529b\uff0c\u70baNMN\u6297\u764c\u9019\u4e00\u89c0\u9ede\u63d0\u4f9b\u4e86\u66f4\u70ba\u5145\u8db3\u548c\u6709\u5229\u7684\u8b49\u64da\uff0c\u4f46\u5c0d\u65bcNMN\u662f\u4fc3\u764c\u9084\u662f\u6297\u764c\u9019\u4e00\u554f\u984c\u9084\u61c9\u8a72\u4fdd\u6301\u8b39\u614e\u7684\u614b\u5ea6\uff0c\u6211\u5011\u4ecd\u9700\u66f4\u591a\u7684\u7814\u7a76\u53ca\u81e8\u5e8a\u8a66\u9a57\u4f86\u9a57\u8b49\u3002\u56e0\u6b64\uff0c\u764c\u75c7\u60a3\u8005\u5efa\u8b70\u9084\u662f\u5225\u670d\u7528NMN\uff0c\u6b63\u5e38\u4eba\u670d\u7528NMN\u662f\u5b8c\u5168\u6c92\u554f\u984c\u7684\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u671f\uff0c\u5c71\u6771\u5927\u5b78\u806f\u5408\u9f4a\u9b6f\u91ab\u9662\u5728\u9802\u7d1a\u671f\u520a\u300aHepatology\u300b\u4e0a\u767c\u6587\uff0c\u4ed6\u5011\u767c\u73fe\u88dc\u5145NMN\u53ef\u4ee5\u986f\u8457\u63d0\u5347\u81ea\u7136\u6bba\u50b7\uff08NK\uff09\u7d30\u80de\u7684\u6d3b\u6027\uff0c\u589e\u5f37\u5176\u6297\u816b\u7624\u53cd\u61c9\u3002NMN\u6297\u764c\u518d\u6dfb\u6709\u5229\u8b49\u64da\uff01 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